Who We Are
Our Study

MWCCS

The MWCCS is a collaborative research effort that aims to understand and reduce the impact of chronic health conditions—including heart, lung, blood, and sleep (HLBS) disorders—that affect people living with HIV. The study is designed to investigate a spectrum of questions relating to the basic science, clinical science, and epidemiology of HIV infection in the U.S., with a focus on comorbidities among men and women living with HIV.  Major areas of investigation include: 

  • Cardiovascular and pulmonary 
  • Neuropsychological 
  • Aging 
  • Cancer 
  • Psychosocial 
  • Health disparities 

MWCCS provides researchers from different disciplines with opportunities to focus on heart, lung, blood, and sleep co-morbidities as well as other conditions known to co-occur with HIV disease, including mental health and neurologic illnesses, diabetes, kidney failure, liver diseases, and certain cancers. This new research effort will build on the valuable information we have already learned from the MACS and WIHS studies and their dedicated participants, including how best to manage HIV, and the link between low immune cell counts and the progression of HIV-associated co-morbidities.

For decades, the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health (NIH), has supported the separate MACS and WIHS cohort studies. MACS was a study of gay and bisexual men, while WIHS was a study of women who had other risk factors for HIV. 

The MWCCS integrates these two longstanding, longitudinal studies and will continue follow-up of the current participants enrolled at 13 MACS/WIHS clinical research sites (CRS) in addition to recruiting new participants with characteristics that reflect the U.S. population living with HIV or at risk for HIV.  

In 2019, the NHLBI became the primary steward of the new MACS/WIHS CCS. For this effort, the NHLBI is working in close collaboration with the NIH Office of AIDS Research (OAR) as well as several co-funding institutes across the NIH. 

While MWCCS is a new study, it has a rich history and will continue to investigate questions at the forefront of HIV research. To learn more about our history and the MACS and WIHS studies, visit Our History.  

JACKSON, MS SAN FRANCISCO, CACHICAGO, ILBROOKLYN, NYBALTIMORE, MDWASHINGTON, DCCHAPEL HILL, NCATLANTA, GABIRMINGHAM, ALBRONX, NYLOS ANGELES, CAMIAMI, FLPITTSBURGH, PACOLUMBUS, OH

ATLANTA, GA

Principal Investigators

Igho Ofotokun, MD, MSc
Emory University

Anandi Sheth, MD
Emory University

Gina Wingood, ScD, MPH
Columbia Univesity

BALTIMORE, MD

Principal Investigators

Todd Brown, MD, PhD
Johns Hopkins University

Joseph Margolick, MD, PhD
Johns Hopkins University

DATA ANALYSIS AND
COORDINATION CENTER – DACC
Principal Investigators

Amber D'Souza, PhD
Johns Hopkins University

Stephen Gange, PhD
Johns Hopkins University

Elizabeth Topper Golub, PhD, MEd, MPH
Johns Hopkins University

BIRMINGHAM, AL/JACKSON, MS

Principal Investigators

Jodie Dionne-Odom, MD
University of Alabama at Birmingham

Mirjam-Colette Kempf, PhD, MPH
University of Alabama at Birmingham

Deborah Konkle-Parker, PhD
University of Mississippi Medical Center

BRONX, NY

Principal Investigators

Kathryn Anastos, MD
Montefiore Medical Center

Anjali Sharma, MD
Albert Einstein College of Medicine

BROOKLYN, NY

Principal Investigators

Deborah Gustafson, MS, PhD
SUNY Downstate Health Sciences University

Tracey Wilson, PhD
SUNY Downstate Health Sciences University

CHAPEL HILL, NC

Principal Investigators

Adaora Adimora, MD, MPH
University of North Carolina at Chapel Hill

CHICAGO, IL

Principal Investigators

Mardge Cohen, MD
Cook County Health and Hospital System

Audrey French, MD
Cook County Health and Hospital System

Steven Wolinsky, MD
Northwestern Univesity

LOS ANGELES, CA

Principal Investigators

Roger Detels, MS, MD
University of California Los Angeles

Matthew Mimiaga, PhD
University of California Los Angeles

MIAMI, FL

Principal Investigators

Maria Alcaide, MD
University of Miami

Margaret Fischl, MD
University of Miami

Deborah Jones Weiss, PhD, MEd
University of Miami

PITTSBURGH, PA/COLUMBUS, OH

Principal Investigators

Jeremy Martinson, PhD
University of Pittsburgh

Charles Rinaldo, PhD
University of Pittsburgh

SAN FRANCISCO, CA

Principal Investigators

Bradley Aouizerat, PhD
New York University

Jennifer Price, MD
University of California San Francisco

Phyllis Tien, MD, MSc
UCSF & San Francisco VA Medical Center

WASHINGTON, DC

Principal Investigators

Seble Kassaye, MD
Georgetown University Medical Center

Daniel Merenstein, MD
Georgetown University Medical Center

 
 
MWCCS