About the CKiD Cohort Study

The Chronic Kidney Disease in Children (CKiD) Study is a multicenter, observational, prospective cohort study of children, adolescents and young adults with a history of mild to moderately impaired kidney function, with sites in the United States and Canada. Participants in CKiD are also followed through their initiation of dialysis or transplant in order to more fully understand the course of this disease and this population’s health beyond kidney replacement therapy (KRT).

CKiD started in 2003, and recently recruited its third wave of participants. Over 1,000 participants have enrolled in CKiD, and many are continuing to be actively followed-up. 

CKiD collects a wide range of data on our participants, such as information on demographics, kidney function, biomarkers for cardiovascular disease, neurocognitive functioning and behaviors, medications, genetics and growth. CKiD is always evolving and adapting to make sure the most relevant and impactful data are being collected.

CKiD is funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the National institute of Child Health and Human Development (NICHD), and the National Heart, Lung, and Blood Institute (NHLBI). 

2003

Study Established

2005-2009

Cohort 1 Enrollment

2011-2014

Cohort 2 Enrollment

2016-2020

Cohort 3 Enrollment

What are CKiD’s main goals?

  • Identify novel and traditional risk factors for disease progression, such as declining GFR and increasing proteinuria, in children, adolescents and young adults with CKD  
  • Characterize the impact of declining kidney function on neurodevelopment, cognitive abilities, and behavior  
  • Identify the prevalence and evolution of cardiovascular risk factors as CKD progresses 
  • Examine the effects of declining kidney function on growth, and to understand the consequence of growth failure in children with CKD  
Learn more about the Study Design

Who is a part of CKiD?

Over 150 investigators, physicians, epidemiologist, statisticians, and coordinators are involved in the maintenance and success of the CKiD Study. These dedicated team members are located at over 50 sites and centers across the United States and Canada. To see a full map of all CKiD Study affiliated locations, please click here.

Most importantly, our participants who take part in our study by coming to annual visits, are the most vital members of the CKiD Study and community. We cannot thank them enough for their time and willingness to let our amazing team of scientists into their lives!

CKiD is supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), and the National Heart, Lung, and Blood Institute (NHLBI).

Learn more about the Study Structure