About CKiD

The CKiD Study is a NIH-funded, multicenter, prospective cohort study of children aged 6 months to 16 years with mild to moderate impaired kidney function. The primary goals of CKiD are to determine the risk factors for decline in renal function and to define how progressive decline in renal function impacts biomarkers of risk factors for cardiovascular disease; neurocognitive function and behavior; and growth failure and its associated morbidity. Two clinical coordinating centers (CCCs) (at Children's Hospital of Philadelphia and at Children's Mercy Hospital in Kansas City), a central biochemistry laboratory (at the University of Rochester), and a data coordinating center (at Johns Hopkins School of Public Health) formed a cooperative agreement to conduct the CKiD Study.

Study Aims

The specific aims are to:

Identify novel and traditional renal disease risk factors for the progression of CKD (e.g. decline of GFR) in children
Characterize the impact of a decline in kidney function on neurodevelopment, cognitive abilities, and behavior
Identify the prevalence and evolution of traditional and novel cardiovascular disease risk factors in progressive CKD
Examine the effects of declining GFR on growth and the treatment of growth failure, and to assess the consequences of growth failure on morbidity in children with CKD

Clinical Coordinating Centers

Children's Mercy Hospital (Bradley Warady, MD)
Children's Hospital of Philadelphia (Susan Furth, MD, PhD)

Data Coordinating Center

Johns Hopkins Bloomberg School of Public Health (Alvaro Muñoz, PhD; Derek Ng, PhD)

Central Laboratories

Central Laboratory at the University of Rochester School of Medicine (George Schwartz, MD)
ABPM Coordinating Center at Univ. of Texas- Houston Medical College (Joshua Samuels, MD, PhD)
Cardiovascular Imaging Core Research Laboratory at Cincinnati Children's Medical Center (Michael Taylor, MD, PhD)
Cardiac MRI Coordinating Center at Cincinnati Children's Medical Center (Michael Taylor, MD, PhD)

Central Repositories

NIDDK Data Repository at Information Management Services (IMS), Calverton, MD
NIDDK Biorepository at Precision for Medicine, Frederick, MD
(biosamples and genetic samples)

National Institutes of Health

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (Ziya Kirkali, MD; Susan Mendley, MD)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (Perdita Taylor-Zapata, MD)
National Heart, Lung, and Blood Institute (NHLBI) (Kristin Burns, MD)