The Women’s Interagency HIV Study (WIHS) is the largest ongoing prospective cohort study of HIV among women in the U.S.

As of January 1, 2019 the Women’s Interagency HIV Study (WIHS) and the Multicenter AIDS Cohort Study (MACS) combined to form the MACS/WIHS Combined Cohort Study (MWCCS). Visit this page for current information about MWCCS. The WIHS website will continue to be maintained as a historical reference for this study.

The Women’s Interagency HIV Study (WIHS) is a large, comprehensive prospective cohort study designed to investigate the progression of HIV disease in women. The WIHS began in 1993 in response to growing concern about the impact of HIV on women. The core study visit includes a detailed and structured interview, physical and gynecologic examinations, and laboratory testing. After more than 20 years, the WIHS continues to investigate questions at the forefront of HIV research, spanning topics such as women’s reproductive health, clinical outcomes (for example, cardiovascular disease, diabetes, and others), and the effectiveness of antiretroviral therapy.

The WIHS Dossier provides key summary statistics about the study and the WIHS Archives document provides a list of all WIHS publications.

The Overview of the WIHS provides information on how the WIHS is structured, areas of focused scientific research, interview components, and how the WIHS data is cleaned and stored.