CKiD Study Information

Study Design

The design of the CKiD study is a prospective, observational cohort of children with chronic kidney disease. Exposures will be measured at baseline and scheduled annual follow-up visits will permit the subsequent updating of the exposures in cohort participants. Outcomes will also be assessed at the annual visits and they include: measures of kidney function; neurocognitive function; markers of risk factors for cardiovascular disease; growth and other co-morbid conditions. The study will use the power of the cohort design with regularly scheduled visits at which markers of disease progression will be measured under standardized procedures. Levels and longitudinal changes in markers will constitute the primary outcomes. The study will collect data on clinical events with primary interest in ESRD and death. Such events will provide time-to-event data to determine heterogeneity of times to ESRD in children with mild to moderate chronic kidney disease.

Study Population

The CKiD study population will include three cohorts. Cohort 1 includes approximately 600 racially and ethnically diverse children, age 1-16 years old with mildly to moderately impaired kidney function, defined by an estimated GFR between 30 and 90 ml/min|1.73m2 by the Schwartz formula (sGFR). Cohort 2 includes approximately 300 children with more mildly impaired kidney function, defined as an estimated GFR between 45 and 90 by the updated Schwartz formula (eGFR). In addition, Cohort 2 was compromised of approximately 150 children with glomerular disease and approximately 150 children with non-glomerular causes of disease. Cohort 3 will include 190 children with non-glomerular diagnosis and duration of kidney disease less than 5 years but age at enrollment could range from 6 months to 16 years old.

Inclusion Criteria

Patients with the non-glomerular diagnoses listed below that meet the initial criteria (i.e., duration of kidney disease less than 5 years, and age between 6 months and 16 years old) are eligible and do not have to meet additional criteria:

However, all other patients with non-glomerular diagnoses will require at least two of the following conditions. All conditions except for abnormal imaging/biopsy must have occurred after the initial 6 months of life and must not be secondary to a current or resolving episode of Acute Kidney Injury (AKI):

Exclusion Criteria

Study Visit Schedule

study visit schedule

Repository Samples

The CKiD Study collects serum, plasma, urine, hair, nails and DNA samples during study visits.