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Biomarkers


Observational studies are being used in Project III's investigation of the role of dietary carcinogens in colon carcinogenesis by use of biomarkers of the exposure. The program project on molecular biomarkers for environmental carcinogens (Dr. John Groopman, Principal Investigator) started in 1993. The long-term goals of this program project are to develop and validate molecular biomarkers reflective of exposure and risk from environmental carcinogens and to use these biomarkers for the design and implementation of prevention strategies in community settings. Several underlying public health based beliefs provide credence for attainment of these goals including, that there are sub-sets of high-risk people within populations that are most susceptible for disease. Thus, methods that can identify these high-risk individuals with high specificity and selectivity will greatly facilitate the implementation of a spectrum of targeted prevention techniques directed towards reducing individual risk. In total, the impact of molecular biomarkers research ranges from exposure assessment, risk assessment and management, to clinical trials. this continuing program project consists of three project areas and two cores. They are:
  • Project I: Molecular Biomarkers for Human Liver Cancer: to define the formation and persistence of biomarkers to aflatoxin exposure relative to risk of disease development by the use of several longitudinal studies including a primary prevention community trial.
  • Project II: Development and Application of Biomarkers to Molecular Interventions in Aflatoxin-Exposed Individuals: studies biomarkers of aflatoxin exposure that can be modulated by chemo prevention are being developed and applied in chemoprevention trials.
  • Project III: Molecular Biomarkers of Exposure and Susceptibility in Human Colon Cancer: Observational studies are being used in the investigation of the role of dietary carcinogens in colon carcinogenesis by use of biomarkers of the exposure.
  • Core A: Biostatistics/Epidemiology Core
  • Core B: Admiinisitrative

Productivity of our collaboration is attested by joint publications [MG Bolton, et al. Cancer Res 1993;53:3499-3504; PA Egner, Carcinogenesis 1995;16:1769-1773; J-S Wang, et al. Cancer Epidemiol Biomarkers Prev 1996;5:253-61; TW Kensler, et al. Cancer Epidemiol Biomarkers Prev 1998;7:127-134] and by methodological contributions [SJ Gange, et al. Cancer Epidemiol Biomarkers Prev 1996;5:57-61].


Biomarkers Publications
A searchable database of all STATEPI publications, including Biomarkers.


This project is funded by the National Institute of Environmental Health Sciences.

This page was last updated October 2001.