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Biomarkers
Observational studies are being used in Project III's investigation
of the role of dietary carcinogens in colon carcinogenesis by use
of biomarkers of the exposure.
The program project on molecular biomarkers for
environmental carcinogens (Dr. John Groopman, Principal
Investigator) started in 1993. The long-term goals of this
program project are to develop and validate molecular
biomarkers reflective of exposure and risk from
environmental carcinogens and to use these biomarkers for
the design and implementation of prevention strategies in
community settings. Several underlying public health based
beliefs provide credence for attainment of these goals
including, that there are sub-sets of high-risk people within
populations that are most susceptible for disease. Thus,
methods that can identify these high-risk individuals with
high specificity and selectivity will greatly facilitate the
implementation of a spectrum of targeted prevention
techniques directed towards reducing individual risk. In total,
the impact of molecular biomarkers research ranges from
exposure assessment, risk assessment and management,
to clinical trials. this continuing program project consists of
three project areas and two cores. They are:
- Project I: Molecular Biomarkers for Human Liver
Cancer: to define the formation and persistence of
biomarkers to aflatoxin exposure relative to risk of
disease development by the use of several
longitudinal studies including a primary prevention
community trial.
- Project II: Development and Application of
Biomarkers to Molecular Interventions in
Aflatoxin-Exposed Individuals: studies biomarkers of
aflatoxin exposure that can be modulated by chemo
prevention are being developed and applied in
chemoprevention trials.
- Project III: Molecular Biomarkers of Exposure and
Susceptibility in Human Colon Cancer: Observational
studies are being used in the investigation of the role
of dietary carcinogens in colon carcinogenesis by use
of biomarkers of the exposure.
- Core A: Biostatistics/Epidemiology Core
- Core B: Admiinisitrative
Productivity of our collaboration is attested by joint
publications [MG Bolton, et al. Cancer Res 1993;53:3499-3504;
PA Egner, Carcinogenesis 1995;16:1769-1773; J-S Wang, et al.
Cancer Epidemiol Biomarkers Prev 1996;5:253-61; TW
Kensler, et al. Cancer Epidemiol Biomarkers Prev 1998;7:127-134] and
by methodological contributions [SJ Gange, et al. Cancer Epidemiol Biomarkers Prev 1996;5:57-61].
Biomarkers Publications
A searchable database of all STATEPI publications, including Biomarkers.
This project is funded by the National Institute of Environmental Health Sciences.
This page was last updated
October 2001.
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